Evaluation of Serum CXCL10 Level as a Prognostic Marker in Colorectal Cancer Patients: A Retrospective Cohort Study

Background: One of the current challenges in cancer management is finding diagnostic and prognostic markers for various cancers. CXCL10 a small protein that defined as an ‘inflammatory’ chemokine binds to CXCR3 mediate immune responses through activation recruitment leukocytes such T cells, eosinophils, monocytes natural killer cells. It facilitates system antitumor activity, causes tumor regression induction angiostasis cellular apoptosis. Most previous studies have reported anti-tumor activity CXCR10, while on its role colorectal are limited. Objectives: The present study aimed evaluate correlation serum level with prognosis patients cancer. Methods: This retrospective cohort was performed 69 histopathological diagnosis oncology ward Razavi Hospital, Mashhad, Iran, between July 2018 September 2019. relationship concentration investigated. Results: results Cox analysis indicated significant patients’ mortality metastasis rate high (P = 0.018 P 0.045, respectively); however, not significantly correlated recurrence 0.81) during four-year follow-up. Conclusions: associated incidence